Array CGH: A Powerful Tool for Detecting Genomic Changes

What is Array CGH?

Array comparative genomic hybridization (array CGH) is a molecular cytogenetic technique used to detect losses or gains of genomic material. It is based on the principle of competitive hybridization, in which two genomes (a test genome and a control genome) are labeled with different fluorescent dyes and hybridized to a DNA microarray. The microarray contains thousands of short DNA probes, each representing a specific region of the genome.

Applications of Array CGH

Array CGH has a wide range of applications in clinical genetics and research. It is used to detect copy number changes in solid tumors, constitutional genetic disorders, and prenatal genetic abnormalities. Array CGH can also be used to identify genomic regions that are associated with specific diseases or traits.

Advantages of Array CGH

Array CGH offers several advantages over traditional cytogenetic techniques, such as: * High resolution: Array CGH can detect copy number changes as small as a few kilobases. * Genome-wide coverage: Array CGH can be used to analyze the entire genome, providing a comprehensive view of genomic changes. * Rapid and cost-effective: Array CGH is a relatively rapid and cost-effective technique.